گزارش یک مورد نشانگان پوئمز (POEMS SYNDROME) از ایران و مروری بر مقالاتی که در این زمینه منتشر شده است.

The crow-fukas, Takatsuki or POEMS syndrome (The acronym of Polyneuropathy, Organomegaly, endocrinopathy, M component and skin changes), a rare, multisystem disorder associated with osteosclerotic myeloma, is characterize by the combination of plasma cell discrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal(M) protein, skin changes, as well as various other sign, such as cachexia, fever, pleural effusion, anasarca, and thrombocytosis. Elevated level of serum interleukin 6(IL-6), tumor necrosis factor alpha (TNF-α) is frequently seen POEMS syndrome is rare in caucasians population and seen more frequently in Japanese persons Treatment is the same as multiple myeloma and symptoms improve with resolution of myeloma. Prognosis is better than multiple myeloma We report interesting case from IRAN with POEMS syndrome and Rheumatoid Factor(RF) elevation. He presents with polyneuropathy, and we find out splenomegaly, adenopathy, clubbing and hyperpigmentation of skin. More evaluation showed plasmacytoma, thyroid dysfunction and elevated level of rheumatoid factor.